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Diazepam is N-demethylated by CYP3A4 and 2C19 towards the Energetic metabolite N-desmethyldiazepam, and is also hydroxylated by CYP3A4 to the active metabolite temazepam. N-desmethyldiazepam and temazepam are both more metabolized to oxazepam. Temazepam and oxazepam are mostly removed by glucuronidation.Diazepam is not really recommended inside the